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Compounded · Menopause & HRT

Estradiol Vaginal Cream

Low-dose, local estrogen for dryness, irritation, and discomfort — right where you feel it.

As estrogen falls, the tissues of the vulva, vagina, and urinary tract can thin and dry out — bringing dryness, irritation, discomfort or pain with sex, and some urinary symptoms. Estradiol vaginal cream 0.01% is a low-dose, local estrogen you apply vaginally with an applicator. It works where you need it, with minimal systemic absorption.

  • Low-dose local estrogen for vaginal dryness, irritation & discomfort with sex
  • Applied vaginally with an applicator — works right where you feel it
  • Minimal systemic absorption — estrogen delivered locally, not body-wide
  • Compounded by a state-licensed U.S. pharmacy, with clinician oversight
  • Direct-to-door · monthly or quarterly plans · cancel monthly anytime before your next ship date
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Your care
Clinician-ledCare
State-LicensedCompounding Pharmacies
HIPAACompliant
Available inAll 50 US states

How it works

Simple online care, built around you.

Start your assessment

3-minute screener · No commitment

1
Complete your intake
Tell us about your health history, goals, symptoms, and what's changed. This takes less than 3 minutes.
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2
Get provider review
A licensed U.S. provider reviews your information and determines whether treatment is appropriate — typically within 24 hours.
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3
Start your plan
If eligible, your plan may include a personalized compounded hormone regimen with pharmacy coordination, ongoing oversight, and direct-to-door delivery.

Our physician partner

Medical oversight by Arora Health

Your care is reviewed and overseen by board-certified, U.S.-licensed physicians at Arora Health & Aesthetics — our independent medical partner, with clinician coverage in all 50 states.

Dr. Sean Arora, Co-Founder and CEO of Arora Health & Aesthetics

Dr. Sean Arora

Arora Co-Founder & CEO

  • Board-certified physician
  • Licensed in all 50 states

Dr. Sean Arora is a board-certified physician and the founder of Arora Health & Aesthetics, bringing deep expertise in wellness, family medicine, and telehealth innovation.

He leads one of the nation's most comprehensive medical oversight and compliance networks, supporting clinics through full-spectrum medical directorship, nationwide telehealth provider coverage, and evidence-based protocol development across peptides, hormone optimization, weight loss, regenerative medicine, and aesthetic treatments.

Known for his forward-thinking approach to patient safety and scalable clinical operations, Dr. Arora partners closely with medical spas, wellness clinics, and telehealth organizations to ensure responsible, compliant, and impactful care. Licensed in all 50 states, he is dedicated to expanding access to high-quality wellness services through innovation, leadership, and patient-centered standards.

Dr. Shannon Arora, Chief Medical Officer of Arora Health & Aesthetics

Dr. Shannon Arora

Chief Medical Officer

  • Hospital-trained physician
  • Preventive & longevity medicine

Dr. Shannon Arora is a physician dedicated to making a meaningful impact on patient health through both traditional medicine and proactive wellness care.

With experience as a hospitalist, she brings a strong clinical foundation shaped by work in hospitals and nursing homes, offering a broad perspective on patient care across diverse settings. While her early career focused on acute care, Dr. Arora recognized an opportunity to create a more proactive, personalized approach within the health, wellness, and longevity space. She now focuses on optimizing patient health through advanced wellness therapies, preventative medicine, and longevity-focused care, helping patients improve energy, confidence, and overall quality of life.

As Chief Medical Officer, Dr. Arora is passionate about advancing innovation in regenerative medicine and wellness, while helping both patients and organizations achieve better outcomes through thoughtful, patient-centered care.

Why local estrogen

Relief delivered right where it's needed.

Woman in midlife at home, relaxed

The tissues of the vulva, vagina, and urinary tract are rich in estrogen receptors. As estrogen falls through perimenopause and menopause, those tissues can thin and lose moisture — leading to dryness, irritation, and discomfort. Clinicians call this the genitourinary syndrome of menopause.

Local vaginal estrogen works directly on those tissues, helping to restore them where the changes are happening. Because it's applied vaginally rather than taken body-wide, it targets the symptoms at their source.

Low-dose vaginal estrogen has minimal systemic absorption and a more favorable systemic risk profile than systemic estrogen — so for some women who can't or don't want systemic HRT, it can still be an option. Your clinician decides whether it's right for you. Many women describe improved comfort and less pain with sex, though responses vary and we don't promise a specific result.

Using it

A simple vaginal routine. Tuned to you.

1
Starting out
Your clinician sets your schedule based on your symptoms and history. Many women start with a more frequent initial period — using the supplied applicator to apply the cream vaginally — before stepping down to a lower maintenance frequency. Your clinician sets the exact schedule.
2
Maintenance
Once your symptoms are settled, most women move to a lower maintenance frequency — often a couple of times a week — applied at bedtime so it stays in place. Your clinician confirms the right cadence for you.
3
Ongoing · Care, not just refills
Your plan includes clinician check-ins, schedule adjustment, and side-effect support — plus a clear conversation about whether progesterone applies to your situation.

Side effects & safety

What to know before you start.

Woman reviewing health information at home

Most common: local irritation, itching, or discharge at the application area, and sometimes spotting, especially in the first weeks. These are often mild and tend to settle.

Worth knowing: low-dose vaginal estrogen has minimal systemic absorption and a more favorable systemic risk profile than systemic estrogen. It is still estrogen, however, and carries a class warning. Women with a history of certain hormone-sensitive cancers or unexplained vaginal bleeding should discuss this with their clinician before starting.

Progesterone: for low-dose vaginal estrogen, routine progesterone is often not required — even for women who still have a uterus — because so little estrogen reaches the rest of the body. Your clinician makes this call based on your dose and history. Tell your clinician about all medications and your full health history.

Questions

Answers to
common questions.

Is this the same as systemic HRT for hot flashes?
No — this is local estrogen for genitourinary symptoms.
No. Vaginal estradiol cream is a low-dose, local treatment aimed at dryness, irritation, and discomfort in the vaginal and urinary tissues. If your main concern is hot flashes or night sweats, a systemic option may be more appropriate. Your clinician advises on the right approach for your symptoms.
Do I still need progesterone?
For low-dose vaginal estrogen, often not — but your clinician decides.
With low-dose vaginal estrogen, so little reaches the rest of the body that routine progesterone is often not required — even for women who still have a uterus. This depends on your dose and history, so your clinician makes the call and explains it for your situation.
When and how do I apply it?
Vaginally, with the supplied applicator — usually at bedtime.
The cream is applied vaginally using the supplied applicator, typically at bedtime so it stays in place overnight. Many women begin with a more frequent initial period and then step down to a lower maintenance frequency. Your clinician sets the exact schedule and your instructions walk you through each step.
When am I charged?
Not until a clinician confirms your eligibility.
You're not charged when you submit. Your card is saved. A licensed clinician reviews your assessment, typically within 24 hours. If approved, you'll be notified by email before the first charge. If not approved, you're not charged.
Can I cancel?
Yes — with full transparency on what you've committed to.
Yes. The monthly plan can be cancelled anytime before your next ship date. The quarterly plan is a committed term — cancel future renewals after the term ends.
Can I use my FSA/HSA?
Yes — itemized receipts provided for self-submission.
Yes. HSA and FSA cards are accepted on any plan. We also provide itemized receipts in case you need to self-submit to your benefits provider.

Find out if vaginal estrogen fits your picture.

The symptom-led assessment is free. If you're a candidate, your clinician typically follows up within 24 hours.

Start my assessment
Start my assessment